One major player, Celera Genomics of Rockville, a subsidiary of PE Corporation, makes a version of the latest gene sequencer
. Another major gene patenter, Incyte Pharmaceuticals of Palo Alto, California, has close ties with Amersham Pharmacia, which makes a competing version of the machine.
Jrassic Park, however, it just science fiction, Hood says, despite the fact that Hood's gene sequencers
are used in the story (pages 39 and 100 of the paperback).
These diverse data and reagents are being generated by investigators from several different research communities, including geneticists, gene sequencers
, gene mappers, cell biologists, developmental biologists, and bioinformatics experts.
The massive effort was enabled through four distinct high efficiency tools: efficient experimental design, targeted restriction enzymes building combinatorial libraries, high throughput automated gene sequencers
and computer based informatics.
The substantial progress in the field of molecular biology, including automated gene sequencers
, industrial use of the PCR, and results from the Human Genome Project, has yielded microfabricated arrays of specific cDNA or specific oligonucleotide sequences.
Buckler's laboratory looks a bit like a beehive, with seven technicians and students and a postdoctoral molecular biologist busily working at automated gene sequencers
. Before he can apply any statistics, each of those 30 genes has to be sequenced--or spelled out base by base--for each of the 100 core lines.
Similarly, they would have said that it is not advisable or necessary to give patents to people who merely put up the money to buy automatic gene sequencers
and similar laboratory equipment, the output of which is transcribed into patent applications.