gene dosage


Also found in: Wikipedia.

gene dosage

the number of copies of a given GENE in a specific CELL or NUCLEUS.
References in periodicals archive ?
EGFR mRNA expression by qRT-PCR, EGFR gene dosage by qPCR, and EGFR copy number by FISH in patients with gefitinib treated non-small cell lung cancer were analyzed in order to determine the association with treatment outcome, clinical, and biological features [34].
These genes located on chromosome 8-such as c-MYC in 8q24, MOS in 8q22, ETO in 8q21.3-may play a significant role in the biology of myeloid lineage disorders via increased gene dosage leading to over-expression (14).
New York, NY, November 27, 2018 --(PR.com)-- A research group led by Hong Xue at Hong Kong University of Science and Technology, unveiled resources & recommendations that propose a new approach for investigator qualification - "analyzing the gene dosage impacts of GABAA receptor ?2 subunit gene (Gabrb2) in knockout mice of both heterozygous (HT) and homozygous (KO) genotypes concerning possible schizophrenia-like and comorbid phenotypes with microglia-dysregulation - a medical study that goes beyond repetitive training and includes individual experience and protocol-particulate preparation.
(9) suggested that the over expression of genes located on the X chromosome may have a gene dosage effect and may cause the developmental anomalies in the genitourinary system of triple X patients.
Its genetic etiology affects the expression of the Proteolipidic Protein type 1 (3,4), varying from hemizygous mutations to gene dosage alterations of the PLP1 (Xq22).
Inherited deficiency of Scn1a gene dosage is known to cause Dravet Syndrome, a severe form of epilepsy.
In contrast to adoption studies, classical comparison of Monozygotic (MZ) and Dizygotic (DZ) twin studies assume that within-family environmental factors are controlled by gene dosage. In this way gene dosage permits the refutation or confirmation of genetic hypothesis.
By this approach, it was found that Hsa21 gene expression was globally upregulated 1.5 fold in trisomic samples, in general agreement with the gene dosage hypothesis.
The selections that make up the main body of the text are devoted to expression noise, protein misfolding, and gene dosage in the evolution of genomes; transition metals and virulence in bacteria, evolution in the cycles of life, and a wide variety of other related subject areas.
Furthermore, the quantitative multiplex PCR allowed for the determination of gene dosage and the accurate identification of DMD deletion carriers (6).
PMP22 Gene Dosage Change: Potential Therapy for CMT1A