copy number

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copy number

  1. the number of copies of a particular PLASMID per CHROMOSOME present in a CELL.
  2. the number of copies of a GENE in the GENOME of an ORGANISM.
References in periodicals archive ?
Since the HC had been integrated into the CHO DG44 genome coupled with DHFR gene; genomic amplification using MTX was used for increasing the HC gene copy number. Only STD7 transformant showed acceptable response to this treatment.
In line with American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines,22,23 an absolute HER2/neu gene copy number of less than 4 or an HER2/neu to Cep17 ratio of less than 2.2 was considered HER2/ neu negative, whereas an absolute HER2/neu gene copy number higher than 6 or a HER2/neu to Cep17 ratio higher than 2.2 was considered HER2/neu positive; however, unlike the ASCO/CAP guidelines, an equivocal class (absolute HER2/neu gene copy number between 4and6oranHER2/neu to Cep17 ratio between 1.8 and 2.2) was not considered, and tumors were classified as positive or negative on the basis of a cutoff value for this ratio of 2.1.
Identification of gene copy number variations in patients with mental retardation using array-CGH: novel syndromes in a large French series.
The gene copy number level of EGFR in pleural effusion was detected by fluorescence in situ hybridization (FISH).
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet.
CytoScan Cytogenetics Suite and OncoScan FFPE Assay Kit are genetic analysis platforms used to analyse gene copy number variation (CNV) in cancer research.
Abnormalities of chromosome 17 are frequent in breast cancer, and the measurement of ERBB2 gene status depends on the criteria used, a ratio of the ERBB2 copy number to the chromosome 17 centromere enumerating probe number (i.e., the HER2/CEP17 ratio) [greater than or equal to] 2.0, a ratio >2.2, or a mean ERBB2 copy number [greater than or equal to] 6.0; however, some tumors that show ERBB2 gene amplification according to an ERBB2 gene copy number [greater than or equal to] 6 do not exhibit amplification according to the ERBB2/CEP17 ratio (6).
The status of EGFR and the patient's response to EGFR-TKI have been assessed by various methods, such as immunohistochemistry (protein expression) and FISH/chromogenic in situ hybridization (CISH) (gene copy number changes), but mutational analysis has been shown to be the best predictor of tumor response to EGFR-TKI.36-40 Therefore, only EGFR mutation testing in NSCLC has been recommended in Europe.
17 April 2014 - US data analytics company CollabRx Inc (NASDAQ:CLRX) and microarray technology and genomics analysis specialist Affymetrix Inc (NASDAQ:AFFX) have agreed to optimise the use of CollabRx's Genetic Variant Annotation (GVA) Service in relation to Affymetrix's OncoScan FFPE Assay Kit and CytoScan Cytogenetics Suite for analysis of gene copy number variation (CNV) in cancer research.
In addition to EGFR mutations, several other markers can predict response to and benefit from EGFR inhibitors, including clinicopathologic features, EGFR protein expression by immunohistochemistry, EGFR gene copy number changes, and other oncogenic mutations such as Kirsten rat sarcoma viral oncogene homolog (KRAS) gene mutations as a negative predictor.
Yet another unreliable position is in exon 8, where the gene copy number is determined with the mutation c.952C>T (p.Gln318X) as the ligation site.
The research, comprising 468 patients, utilised innovative approach involving genome-wide investigation of gene copy number variants (CNVs), followed by targeted sequencing of CNV-identified candidate genes.