gene conversion

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gene conversion

n.
1. The unequal segregation of alleles to gametes during meiosis, resulting in gametes containing one allele being more numerous than gametes containing the other allele for certain genes.
2. The replacement of one part of a chromosome with a copy of the homologous part on the sister chromosome, often as a consequence of DNA repair.

gene conversion

DNA RECOMBINATION process that results in one ALLELE in a HETEROZYGOTE being converted into the corresponding allele. Conversion can be a consequence of the mode of repair (see DNA REPAIR) of the base-pair mismatch (HETERODUPLEX) that accompanies recombination in MEIOSIS. The process can result in the four haploid products of meiosis exhibiting an unusual (aberrant) segregation pattern.