gene conversion


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gene conversion

n.
1. The unequal segregation of alleles to gametes during meiosis, resulting in gametes containing one allele being more numerous than gametes containing the other allele for certain genes.
2. The replacement of one part of a chromosome with a copy of the homologous part on the sister chromosome, often as a consequence of DNA repair.

gene conversion

DNA RECOMBINATION process that results in one ALLELE in a HETEROZYGOTE being converted into the corresponding allele. Conversion can be a consequence of the mode of repair (see DNA REPAIR) of the base-pair mismatch (HETERODUPLEX) that accompanies recombination in MEIOSIS. The process can result in the four haploid products of meiosis exhibiting an unusual (aberrant) segregation pattern.
References in periodicals archive ?
Gene conversion and functional divergence in the beta-globin gene family.
Second, because most of the functional genes on the Y occur in palindromes, they will be maintained by the gene conversion methods that maintain them now.
That aspect of gene conversion may be a key to helping humans in the genetic arms race against malaria.
GC-Content evolution in mammalian genomes: The biased gene conversion hypothesis.
(3.) Hillis DM, Moritz C, Porter CA, Baker RJ, Evidence for biased gene conversion in concerted evolution ofribosomal DNA.
Instead, their evidence suggests that a separate process known as BGC (biased gene conversion) has speeded up the rate of evolution in certain genes.
The novel alleles at the opaB and opaD loci in genocloud 2 bacteria from Moscow probably represent gene conversion with the opaJ101 and opaA132 alleles (Figure 4).
formosa hybrid are still represented by an extant taxon rather than belonging to an extinct species, and that gene conversion does not play an important role in shaping the hybrid genome of the Amazon molly.
(2.) Hillis D M, Moritz C, Porter C A & Baker R J, Evidence for biased gene conversion in concerted evolution of ribosomal DNA, Science, 1991; 251: 308-310.
vivax in S-type rRNA Genes: Result of a Single-Type Gene Conversion
Intergenic recombinations are relatively frequent in this region (14), and are responsible for 95% of the mutations associated with 210HD; the remaining 5% of mutations are apparently not the result of gene conversion events (1-15).
Four general mechanisms for antigenic variation have been described (10): modification of transcript levels, gene conversion, DNA rearrangement, and multiple point mutations (Figure 2).