MMP-2 and MMP-9 are members of
gelatinase group and are able to degrade gelatin and collagen (2).
Net gelatinolytic activity reflects the proteolytic activity of
gelatinases in a specific tissue [22].
Our results demonstrate that AREG enhances
gelatinase protein expression via engagement with EGFR.
Tetracyclines are a class of antibiotics which inhibit the catalytic activity of human collagenases and
gelatinases, especially MMPs.
One way Analysis of Variance (ANOVA) was used to analyse relative gene expression and densitometry of
gelatinase bands.
Degradation of basement membranes by
gelatinases that are only metalloproteinases able to degrade basement membrane collagen (type IV) may result in the formation of distant metastases.
Crabbe, "
Gelatinases A and B," Methods in Enzymology, vol.
Gelatinases MMP-2 and MMP-9 were produced by both ASC and CE (Figures 2(e) and 2(f)).
Fainardi et al., "Effects of anticoagulants on the activity of
gelatinases," Clinical Biochemistry, vol.
MMP-2, MMP-3, MMP-9, MMP-13, and MT1-MMP have all been identified in neuronal nuclei and
gelatinases (MMP-2 and MMP-9) and MMP-3 have been implicated in the progression of infarct volume and neuronal death in animal models of stroke and ischemic stroke patients [9,16,18, 23, 29-33].
[9-11] MMP-9 (
Gelatinase B) is released by neutrophils, monocytes, macrophages, and eosinophils in the course of inflammatory response.
Collagenases,
gelatinases, stromelysin-3, matrilysin, MT1-MMP [99], and stromelysin-1 [100] are considered the most closely associated to the invasive phenotype.
