gelatinase


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gel·a·tin·ase

(jĕ-lat'i-nās),
Pepsin B; a metalloproteinase that hydrolyzes gelatin and a number of types of collagen. See: pepsin.

gelatinase

(jĕl′ă-tĭn-ās),

MMP-2; MMP-9

Metalloproteinases that cleave gelatin, or nondenatured collagen. Two forms of gelatinase, A and B, have been identified. Gelatinase A (MMP-2) has a molecular weight of about 72,000, and gelatinase B (MMP-9) has a molecular weight of about 92,000. Both are involved in cancer angiogenesis and metastasis and are blocked by a variety of naturally occurring and synthetic inhibitors.
References in periodicals archive ?
A inativacao da gelatinase B (MMP-9) retardou a vascularizacao e ossificacao das linhas de crescimento osseo (17), alem de diminuir a fertilidade (18).
2% were gelatinase positive, caseinase all were negative, 9.
High concentrations of gelatinases are found in invasive tumors, and allow tumor cells to invade normal tissues.
Gelatinases, a class of enzymes, have been implicated in a host of human diseases from cancer to cardiovascular conditions and in particular neurological conditions such as stroke, aneurysm and traumatic brain injury.
Among the As(V) isolates (n = 12) tested with API 20E[R] strips, five were positive for [beta]-galactosidase, two were positive for arginine dihydrolase, and seven were positive for gelatinase.
The ability of the bacterial isolates to produce various hydrolytic enzymes such as amylase, gelatinase and lipase were determined using the plate assay.
Doxycycline is thought to inhibit gelatinase, which breaks down components of the skin's extracellular matrix.
The interplay of collagen IV, tumor necrosis factor-[alpha], gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis," Endocrinology 144(1): 371-387.
The Chanel laboratories have developed an ultra-targeted formula called Precision Age Delay Eye, which combines extract, of horse chestnut with a marine polysaccharide (a powerful inhibitor of gelatinase A, an enzyme said to play a key role in the aging of the eye area), and a lipopeptide, also used in the Age Delay serum for the face.