Gaucher cell


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Gaucher cell

A large reticuloendothelial cell seen in Gaucher disease, which contains a small, eccentrically placed nucleus and kerasin.
References in periodicals archive ?
This is related to a vigorous inflammatory response to the enlarged Gaucher cells. The splenomegaly can lead to severe anemia, leukopenia, thrombocytopenia, and life-threatening splenic infarcts.
An increased incidence of gammopathies and multiple myeloma has been reported, further showing the interplay between Gaucher cells and the immune system [49].
Microscopically, Spleen showed nodular & diffuse infiltrates of "Gaucher cells" in red pulp and these were PAS positive.
(1) This partial enzyme deficiency results in accumulation of glycosphingolipid-laden macrophages (Gaucher cells) throughout the liver, spleen, bone marrow, skeleton and occasionally the lung.
Pulmonary hypertension in Gaucher disease is not common but it is shown to be secondary to interstitial or perivascular infiltration of Gaucher cells or primary in patients exposed to enzyme replacement therapy (ERT).