gatifloxacin


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gatifloxacin

 [gat″ĭ-flok´sah-sin]
a broad-spectrum antibiotic effective against many gram-positive and gram-negative bacteria; administered orally and intravenously in the treatment of bacterial complication of chronic bronchitis, acute sinusitis, community-acquired pneumonia, gonorrhea, pyelonephritis, and urinary tract infections due to susceptible organisms.

gatifloxacin

/gat·i·flox·a·cin/ (gat″ĭ-flok´sah-sin) a fluoroquinoloneantibacterial effective against many gram-positive and gram-negative bacteria.

gatifloxacin

a broad-spectrum antiinfective.
indications It is used to treat acute bacterial exacerbation of chronic bronchitis, acute sinusitis, community-acquired pneumonia, gonorrhea, and infections caused by susceptible Escherichia coli, Staphylococcus aureus, Haemophilus influenzae, H. parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Neisseria gonorrhoeae, Proteus mirabilis, Chlamydia pneumoniae, Legionella pneumophila, and Mycoplasma pneumoniae.
contraindications Known hypersensitivity to quinolones prohibits its use.
adverse effects Pseudomembranous colitis is a life-threatening effect. Other adverse effects include dizziness, insomnia, paresthesia, tremor, vasodilation, increased aspartate aminotransferase and alanine aminotransferase, pruritus, urticaria, photosensitivity, flushing, fever, and chills. Common side effects include headache, nausea, diarrhea, rash, dyspnea, and pharyngitis.

gatifloxacin

a fluoroquinolone antibiotic with activity against anaerobic bacteria.
References in periodicals archive ?
Results: The rate of resistance to trimethoprim-sulfamethoxazole was up to 27 (18%) and the highest resistance to quinolone family belonged to ofloxacin (20%) and the lowest rate was for gatifloxacin (16%).
aureus strains, susceptibility to antibiotics was as follows: amikacin- (26 cases), gentamycin-(9 cases), ciprofloxacin-(10 cases) and gatifloxacin (15 cases) [Table 4].
for 15 days (Tab Marbomet (a)) and Gatifloxacin ear drops (Gatiquin-P (b)) @ five drops three times daily for seven days.
The panel of antibiotics used was penicillin, cloxacillin, erythromycin, azithromycin, amikacin, gentamicin, ciprofloxacin, gatifloxacin, tetracycline, cephalexin, cefuroxime, cefoperazone, piperacillin+tazobactum, linezolid and vancomycin.
In an advisory, the FDA said these unregistered drug products are Moxifloxacin Hydrochloride (Moxibright) 5 mL Eye Drops, Moxifloxacin Hydrochloride + Dexamethasone Sodium Phosphate (Moxibright DM) 5 mL Eye Drops, Carboxymethyl Cellulose Sodium + Glycerin (Tearbright Plus) 10 mL Eye Drops, Gatifloxacin + Prednisolone Acetate (Gatsun-P) 5 mL Eye Drops and Moxifloxacin Hydrochloride (Occumox) 5 mL Eye Drops.
Objective: To assess the efficacy of Gatifloxacin 0.
The weight of the evidence tends to show a higher rate of hypoglycaemia with gatifloxacin than with levofloxacin or ciprofloxacin, the other fluoroquinolones most commonly associated with hypoglycaemia.
A retrospective database analysis of published case reports of patients who received FQs over a 15-year period found 25 cases of torsades de pointes; moxifloxacin (highest), levofloxacin, and gatifloxacin (which was taken off the market by the FDA in 2006) (20) were associated with a higher incidence than ciprofloxacin, (21) Ciprofloxacin appears to be the safest FQ for cardiovascular events, with the lowest reported risk of torsades de pointes.
Gatifloxacin (Tequin[R]) was withdrawn from the market in 2006 because of its association with dysglycemia, and these antibiotics may cause hypoglycemia by increasing the body's release of insulin.
6) It has been reported that the new generation of fluoroquinolones, such as moxifloxacin and gatifloxacin, showed favorable pharmacokinetic activity and lower minimum inhibitory concentrations (MIC) against Mycobacterium tuberculosis.
The resistance patterns to levofloxacin were identical to those of gatifloxacin across all the isolates that were tested for both of these antibiotics in our study.