gastrointestinal stromal tumor

(redirected from Gastrointestinal stromal cell tumor)

gastrointestinal stromal tumor

[MIM*606764]
benign or malignant tumor composed of unclassifiable spindle cells; immunohistochemically distinct from smooth muscle and Schwann cell tumors.

gastrointestinal stromal tumor

GIST Surgical pathology A nonmucosal GI tumor most common in the stomach Clinical Benign–leiomyoma or malignant–leiomyosarcoma, determined histologically by ↑ mitotic activity and bizarre cells, findings seen in aggressive lesions. See Leiomyoma, Leiomyosarcoma.

gas·tro·in·tes·ti·nal stro·mal tu·mor

(gas'trō-in-tes'ti-năl strō'măl tū'mŏr)
Benign or malignant tumor composed of unclassifiable spindle cells; immunohistochemically distinct from smooth muscle and Schwann cell tumors.
References in periodicals archive ?
Brugge, "A guide for the diagnosis and management of gastrointestinal stromal cell tumors," Nature Reviews Gastroenterology & Hepatology, vol.
The proto-oncogene c-kit encodes a 145-kd transmembrane tyrosine kinase receptor (CD117), the ligand of which is stem cell factor (SCF).[13-15] Expression of c-Kit is weak to moderate in a wide variety of normal, benign, and malignant tissues.[16-18] In a subset of mast cell disorders[19] and gastrointestinal stromal cell tumors,[20,21] over-expression has been linked to either an activating or dominant-inactivating c-kit mutation.

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