ganglioside

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ganglioside

 [gang´gle-o-sīd]
a class of galactose-containing cerebrosides found in central nervous system tissues; they are glycolipids of the basic composition ceramide-glucose-galactose-N-acetyl neuraminic acid. The form GM1 accumulates in tissues in generalized gangliosidosis, the form GM2 in Tay-Sachs disease.

gan·gli·o·side

(gang'glē-ō-sīd),
A glycosphingolipid chemically similar to cerebrosides but containing one or more sialic (N-acetylneuraminic or N-glycolylneuraminic) acid residues; found principally in nerve tissue, spleen, and thymus; ganglioside GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease.

ganglioside

(găng′glē-ə-sīd′)
n.
Any of a group of galactose-containing cerebrosides found in the surface membranes of nerve cells.

gan·gli·o·side

(gang'glē-ō-sīd)
Glycosphingolipid chemically similar to cerebrosides but containing one or more sialic acid residues; found principally in nerve tissue, spleen, and thymus; GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease.

ganglioside

A compound of fat and carbohydrate (glycolipid) that is an important component in cell membranes.

Ganglioside

A fatty (lipid) substance found within the brain and nerve cells.
Mentioned in: Tay-Sachs Disease
References in periodicals archive ?
Tissue receptor for cholera exotoxin postulated structure from studies with GM1 ganglioside and related glycolipids.
(12,18) It is thought that the accumulation of gangliosides within cell membranes results in a relative reduction of Cho precursors, thus minimising MRS evidence of demyelination.
Gangliosides fall into a class of molecules called glycosphingolipids.
A mixture of gangliosides given by subcutaneous injection was more effective than placebo, but poor tolerability and derivation from bovine brain tissue severely limit its acceptability.
Each of these cell lines makes antibodies that bind to a specific ganglioside. When one of these antibodies binds to its matching ganglioside on a cancer cell, it triggers an immune response that kills the cell.
These findings support the hypothesis that the sialic acid in human milk may contribute significantly to greater concentrations of gangliosides in the brains of breastfed infants and to the observed neurological and intellectual advantages of breastfeeding over formula feeding.
The analysis of SL composition of both cell lines (Figure 1) showed that CuFi-1 cells have an increased content of Cer and GlcCer, followed by a slight reduction of ganglioside GM3 compared to NuLi-1 cells.
GM2 gangliosidoses are caused by a lysosomal storage of ganglioside GM2 and related gangliosphingolipids in neurons and glial cells.
Typically, an infection eventually triggers autoantibodies targeting gangliosides in the membrane of nervous cells, causing respiratory or gastrointestinal symptoms before more obvious neurologic/motor impairment.
AMAN has been strongly associated with antibodies to gangliosides GM1 and GD1a in axons of peripheral nerves3.
In this context, herein we investigated the role of gangliosides, which are sialic acid-containing glycosphingolipids (GSLs) ubiquitously distributed in cell membranes [5], in the osteogenic differentiation of hTSCs.
It is caused by a deficiency of beta-galactosidase (GLB1), a lysosomal hydrolase that maybe defective with respect to keratan sulfate in Morquio B disease (MBD) or to gangliosides, lactosylceramide, asialofetuin, and oligosaccharides carrying terminal beta-linked galactose and keratan sulfate in GM1-gangliosidosis [2].