Analysis of BRAF V600E mutation in 1.320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma
and extra-cerebellar pilocytic astrocytoma.
IHCMicrophotograph (40x) of Ganglioglioma
showing Positive GFAP Staining in the Neoplastic Ganglion Cell Cytoplasm and Fibrillary Processes
BRAF V600E is present in a wide range of brain tumors, including ganglioglioma
(~30%), pleomorphic xanthoastrocytoma (~40%), and epithelioid GBM (~50%), and is mutually exclusive with BRAF fusions.
was qualified as anaplastic due to increased cellularity, nuclear atypia, and mitotic activity in the glial component (Figure 2).
In summary this report presents a rare case of suprasellar ganglioglioma
in a young male.
A magnetic resonance imaging scan was subsequently done, and the report suggested the presence of a large, left frontal lobe, multicystic inhomogenous tumour with characteristics consistent with a ganglioglioma
or pleomorphic xanthoastrocytoma.
Dentro de la patologia tumoral se encontro un astrocitoma pilocitico, un ganglioglioma
, un gangliocitoma y un tumor neuroepitelial disembrioplasico.
Jesse has been plagued since birth with an extremely rare ganglioglioma
brainstem tumour, believed to be the first case formally on record in New Zealand.
Walnut Creek, CA, April 17, 2013 --(PR.com)-- Just nine years ago, Carlos Cabrera's life was dramatically changed when he was diagnosed with a rare brain tumor called ganglioglioma
. He survived, but was left with visible scarring that reminded him daily of the trauma he had experienced.
Other tumours were the final diagnosis in 7 patients (3 oligodendrogliomas, 2 meningiomas, 1 dysembryoplastic neuroepithelial tumour (DNET) and 1 ganglioglioma
) while 'tumour-like lesions' was the final diagnosis in 3 lesions initially believed to be brain tumours on conventional MRI (infarction secondary to vasculitis, radiation injury and brain abscess).
Tumor histology of pediatric patients with brain tumors (n=136) Tumor N Pilocytic astrocytoma (WHO grade I) 42 Medulloblastoma 12 Ependymoma (WHO grades I , II, III) 11 Astrocytoma (WHO grade II) 11 Craniopharyngioma 11 Astrocytoma (WHO (grades III & IV) 6 Choroid plexus papilloma (WHO grade I) 5 Germinoma 5 PNET 5 Dermoid cyst 4 SEGA (WHO grade I) 4 Meningioma 3 Ganglioglioma
(WHO grade I) 2 Metastatic 2 Oligodendroglioma (WHO grade II) 3 Choroid plexus carcinoma (WHO grade III) 1 Epidermoid cyst 1 Hemangiopericytoma 1 Pilomyxoid astrocytoma 1 Pineocytoma (WHO grade II) 1 Pleomorphic xanthoastrocytoma 2 Rathke's cleft cyst 1 Schwannoma (WHO grade I) 1 Pituitary adenoma 1 Table 3.
Representative samples from the tumor were sent for frozen section and were reported as ganglioglioma
arising from the sympathetic chain.