cystatin C

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cystatin C

(sĭs′tăt-ĭn)
A cysteine proteinase inhibitor found in the bloodstream in elevated concentrations in patients with impaired kidney function. It is a small protein composed of 120 amino acids (mass 13 kD) that is produced by nucleated cells throughout the body and easily filtered by the glomeruli of the kidneys. It is reabsorbed and catabolized by proximal tubular cells. Because levels of cystatin C do not depend on a patient's age, height, muscle mass, or weight, it is thought to be a better measure of kidney function than the creatinine clearance test, which is most often used to assess renal health.
References in periodicals archive ?
Quantitation of gamma-trace in human biological fluids: indications for production in the central nervous system.
C (gamma-trace) as a measure of the glomerular filtration rate.
Human gamma-trace. Structure, function and clinical use of concentration measurements.
Human gamma-trace, a basic microprotein: aminoacid sequence and presence in the adenohypophysis.
The cerebrospinal fluid and plasma concentrations of gamma-trace beta2 microglobulin at various ages and in neurological disorders.