GADD45A

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GADD45A

A gene on chromosome 1p31.2 that is upregulated in response to stressful growth-arrest conditions and exposure to DNA-damaging agents. The encoded protein activates the p38/JNK pathway via MTK1/MEKK4 kinase.
References in periodicals archive ?
[24.] Kastan MB, Zhan Q, el-Deiry WS, Carrier F Jacks T, Walsh WV, et al, A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia, Cell 1992; 71: 587-97, [CrossRef]
In a variety of organisms, tissues, and cell types, FOXO3a increases mitochondrial biogenesis and expression of TFAM [329], but is more known for increasing expression of antioxidant and repair proteins, including SOD2 [287, 330, 331], catalase [287, 330, 332, 333], glutathione S-transferase (GST) [322], thioredoxins [287,323], Prx3 [287, 334], Prx5 [287], and metallothioneins I and II [322], as well as UCP2 [287, 322] and the DNA repair enzyme growth arrest and DNA damage-inducible 45 (GADD45) [322, 324, 335, 336].
El-Deiry et al., "A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia," Cell, vol.
The GADD45 family is a key player in stress-induced cell arrest, for example, through oxidative stress or DNA damage [44].
Locker, "Gadd45 in the liver: signal transduction and transcriptional mechanisms," in Gadd45 Stress Sensor Genes, D.
In vitro effects of infrared A radiation on the synthesis of MMP1, catalase, superoxide dismutase and GADD45 alpha protein.
GADD45 alpha mediates arsenite-induced cell apoptotic effect in human hepatoma cells via JNKs/AP-1-dependent pathway.
PCNA has been reported to participate in the regulation of apoptosis, either by suppressing antiapoptotic proteins, including the Gadd45 family (Gadd45, Myd118, and CR6) in somatic cells, or by promoting proapoptotic proteins, such as ING1 [45-47].
Analysis of the mammalian gadd45 gene and its response to DNA damage.
Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells.
GADD45, PRDX3) targets; DNA repair genes/ proteins BRCA1, H2AFX and PARP-1; and tumor suppressor P16 gene expression.
Hoyoko, "Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells," In Vivo, vol.