[24.] Kastan MB, Zhan Q, el-Deiry WS, Carrier F Jacks T, Walsh WV, et al, A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45
is defective in ataxia-telangiectasia, Cell 1992; 71: 587-97, [CrossRef]
In a variety of organisms, tissues, and cell types, FOXO3a increases mitochondrial biogenesis and expression of TFAM , but is more known for increasing expression of antioxidant and repair proteins, including SOD2 [287, 330, 331], catalase [287, 330, 332, 333], glutathione S-transferase (GST) , thioredoxins [287,323], Prx3 [287, 334], Prx5 , and metallothioneins I and II , as well as UCP2 [287, 322] and the DNA repair enzyme growth arrest and DNA damage-inducible 45 (GADD45
) [322, 324, 335, 336].
El-Deiry et al., "A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45
is defective in ataxia-telangiectasia," Cell, vol.
family is a key player in stress-induced cell arrest, for example, through oxidative stress or DNA damage .
in the liver: signal transduction and transcriptional mechanisms," in Gadd45
Stress Sensor Genes, D.
alpha mediates arsenite-induced cell apoptotic effect in human hepatoma cells via JNKs/AP-1-dependent pathway.
PCNA has been reported to participate in the regulation of apoptosis, either by suppressing antiapoptotic proteins, including the Gadd45
, Myd118, and CR6) in somatic cells, or by promoting proapoptotic proteins, such as ING1 [45-47].
Analysis of the mammalian gadd45
gene and its response to DNA damage.
Protective roles of Gadd45
and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells.
, PRDX3) targets; DNA repair genes/ proteins BRCA1, H2AFX and PARP-1; and tumor suppressor P16 gene expression.
Hoyoko, "Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45
gene expression in human cancer cells," In Vivo, vol.