GZMB


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Related to GZMB: prf1, PubMed, Granzyme A

GZMB

A gene on chromosome 14q11.2 that encodes an enzyme necessary for target cell lysis in cell-mediated immune responses, and which is linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis. GZMB cleaves caspase-3, -7, -9 and -10, activating enzymes that mediate apoptosis.
References in periodicals archive ?
Considering the quick and widespread dissemination of the pathogen, we investigated the effect of gzmA and gzmB deficiency in distant organs during the progression of the disease.
Given that previous studies have reported elevated levels of gzmA and gzmB in plasma of patients with severe sepsis [11, 12], and that gram-negative bacteria, as well as E.
The present study is the first, to our knowledge, showing the pattern of intracellular expression of gzmA and gzmB by different lymphocyte populations before and after induction of E.
Bregs were defined as [CD19.sup.+][CD5.sup.+][CD38.sup.+] cells producing IL10 and GZMB. (a) Dot plots showing the gating strategy [CD19.sup.+] B cells were defined inside live [CD45.sup.+] cells, and the [CD5.sup.+][CD38.sup.+] double- positive population was identified among the live [CD19.sup.+] B cells.
14 S-MpM 1 0 0 0 Intratumoural lymphocytes Case T cells Tbet GZMB Foxp3 PD1 No.