GZMA


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GZMA

A gene on chromosome 5q11-q12 that encodes a T-cell- and natural killer cell-specific serine protease required for target cell lysis in cell-mediated immune responses.
References in periodicals archive ?
To get insight into the influence of gzmA and gzmB deficiency on the local inflammatory response elicited during septic peritonitis, we measured proinflammatory (TNF-[alpha], IFN-[gamma], and IL-1[beta], IL-6) and anti-inflammatory (IL-10) cytokines as well as MCP-1 and KC levels in PLF.
Considering the quick and widespread dissemination of the pathogen, we investigated the effect of gzmA and gzmB deficiency in distant organs during the progression of the disease.
Given that previous studies have reported elevated levels of gzmA and gzmB in plasma of patients with severe sepsis [11, 12], and that gram-negative bacteria, as well as E.
The present study is the first, to our knowledge, showing the pattern of intracellular expression of gzmA and gzmB by different lymphocyte populations before and after induction of E.