Monforte et al., "Start codon mutation of GYG1 causing late-onset polyglucosan body myopathy with nemaline rods," Journal of Neurology, vol.
Etiologies of NB Myopathy NB in other neuromuscular disorders AD: NEB, ACTA1, TPM3, TPM2 Myopathy Idiopathic inflammatory myopathies Acute alcoholic myopathy AR: ACTA1, TPM3, TPM2, TNNT1, Myotonic dystrophy CFL2, KBTBD13, KLHL40, Sarcoglycanopathies KLHL41, LMOD3, MYPN, MYO18B Mitochondrial myopathy GYG1 polyglucosan body myopathy Late-onset Pompe disease Acquired Neuropathy MGUS Spinal muscular atrophy HIV-associated myopathy Amyotrophic lateral sclerosis Charcot-Marie-Tooth disease Other Hypothyroidism Chronic renal failure Keys: genes are written in italic font; AD, autosomal dominant; AR, autosomal recessive; NB, nemaline body; MGUS, monoclonal gammopathy of undetermined significance.
The proteins in cluster 2 were classified together mainly because they were downregulated at the proliferation stage and changed slightly, even a little, at other time points including NANS, CACNA1A, and GYG1
. The third cluster mainly included proteins downregulated at priming stage and upregulated at the proliferation stage such as ARSA, PPP1CB, NCOR1, HK3, and CDK4.