GUCY1A3

GUCY1A3

A gene on chromosome 4q31.3-q33 that encodes the alpha subunit of a soluble guanylate cyclase, one of a family of nitric oxide-activated heterodimeric enzymes that catalyse the conversion of GTP to 3’,5’-cyclic GMP and diphosphate.
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References in periodicals archive ?
A total of 24 CAD genes, namely, 105 (ADARB2), 183 (AGT), 1586 (CYP17A1), 1611 (DAP), 2917 (GRM7), 2982 (GUCY1A3), 4134 (MAP4), 4625 (MYH7), 4629 (MYH11), 5126 (PCSK2), 5522 (PPP2R2C), 9229 (DLGAP1), 9833 (MELK), 23544 (SEZ6L), 23551 (RASD2), 55017 (C14orf119), 55759 (WDR12), 56776 (FMN2), 60676 (PAPPA2), 60680 (CELF5), 84790 (TUBA1C), 127833 (SYT2), 133491 (C5orf47), and 259232 (NALCN), were identified in this coexpression network (Figure 2, Table S3).
At the level of cGMP/GMP and cAMP/AMP regulation, the downregulation of PDE6D and adenylate cyclase 7 (ADCY7) as well as the upregulation of PDE4B and two soluble forms of guanylate cyclase (GUCY1A3, GUCY1B3) suggest a shift towards cGMP and AMP production.
F2 Resource CPE, GUCY1A3, (2012) Population TDO,GUCY1B3, HOPX, REST Supplementary Table S2.