GTPase


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GTPase

enzyme activity that catalyzes the hydrolysis of guanosine triphosphate to guanosine diphosphate and orthophosphate.

GTPase

guanosine triphosphatase.
References in periodicals archive ?
12/13], which binds to RhoGEF proteins, which then activate the cytosolic small GTPase Rho, which is involved in regulating the cell's cytoskeleton.
Interaction between small GTPase Rab7 and PI3KC3 links autophagy and endocytosis: A new Rab7 effector protein sheds light on membrane trafficking pathways.
All these from the structure proved that T2R1 had the functions of membrane transferring, receptor and GTPase activation.
This hypothesis was supported by the fact that the endocytic protein, GTPase dynamin, binds directly to liposomes, deforming them into tubules in vitro, and plays critical roles in membrane fission and curvature during clathrin-mediated endocytosis.
Lastly, from 240-300 min, the enrichment of "Small GTPase activity" and "Elk-3 transcription factor" expression, we propose, leads to changes in cell adhesion and cell rearrangement, preparing the cell for overall stress response and possible bleaching (Johnson and Nakamura, 2007).
4) The GTP-bound small GTPases subsequently activate the first kinase tier of the MAPK cascade by inducing an allosteric conformational change in the MAPKKKs.
Small GTPase Rab4b participates in the gene transcription of 20-hydroxyecdysone and insulin pathways to regulate glycogen level and metamorphosis.
Neurofibromin (a GTPase activating enzyme GAP) is a tumor suppressor and functions to inhibit the p21 rasoncoprotein8.
Quilliam, "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase," The Journal of Biological Chemistry, vol.
Additionally, the dynamin-related GTPase mitofusin 2 (Mfn2) proteins located on the ER intermingle with Mfn1 or Mfn2 on mitochondria to tighten the connection.
4) Point mutations in codons 12 or 13 impair the intrinsic GTPase activity of KRAS, thereby causing KRAS proteins to accumulate in the GTP-bound, active form.