GTP cyclohydrolase

(redirected from GTP cyclohydrolase I)
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GTP cy·clo·hy·dro·lase

an enzyme that catalyzes the reaction of GTP and H2O forming formate and a precursor of tetrahydrobiopterin; a deficiency of this enzyme will result in one form of malignant hyperphenylalaninemia.
References in periodicals archive ?
GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
Allosteric characteristics of GTP cyclohydrolase I from Escherichia coli.
Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP.
Normal values and age-dependent changes in GTP cyclohydrolase I activity in stimulated mononuclear blood cells measured by high-performance liquid chromatography.
Immobilization of GTP cyclohydrolase I and 6-pyruvoyl-tetrahydropterin synthase to different affinity supports.
A sensitive assay for the enzymatic activity of GTP cyclohydrolase I.
Dopa-responsive dystonia in British patients-new mutations of the GTP cyclohydrolase I gene and evidence for genetic heterogeneity.
Dominant negative effect of GTP cyclohydrolase I mutations in dopa-responsive hereditary progressive dystonia.