G proteins

(redirected from GTP binding proteins)

G pro·teins

intracellular membrane-associated proteins activated by several (for example, β-adrenergic) receptors; they serve as second messengers or transducers of the receptor-initiated response to intracellular elements such as enzymes to initiate an effect. These proteins have a high affinity for guanine nucleotides and hence are named G proteins.
Farlex Partner Medical Dictionary © Farlex 2012

G proteins

Cell messengers that relay signals from over 1000 different cell membrane receptors to many different intracellular effectors such as enzymes and ion channels. G proteins have three subunits, alpha, beta, and gamma, each coded for by a different gene, selected from a total of 34 genes. G protein function is switched on and off by the binding and hydrolysis of guanosine triphosphate to the alpha subunit which is loosely attached to the others. Binding causes the beta and gamma fragments to separate as a dimer and to activate downstream effectors.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
tuberculosis: Mycobacterium tuberculosis AMs: Alveolar macrophages RRTB: Resistance to Rifampicin Tuberculosis MDR-TB: Multidrug-resistant TB SDG: Sustainable Development Goals XDR-TB: Extremely drug-resistant TB GTPases: Guanosine triphosphatases G-proteins: GTP binding proteins PDB: Protein Data Bank NCBI: National Center for Biotechnology Information SAPS: SAP Application Performance Standard I-TASSER: Iterative Threading Assembly Refinement LOMETS: Local metathreading server RAMPAGE: Ramachandran Plot Analysis UniProt-GOA: Gene ontology annotation.
Rho GTPases are a family of GTP binding proteins that mediate actin dynamics and act as important modulators in various steps of cancer progression [21].