GNAS

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GNAS

A locus on chromosome 20q13.3 that has a highly complex imprinted expression pattern, giving rise to maternally, paternally and biallelically expressed transcripts derived from four alternative promoters and 5' exons. Some transcripts have a differentially methylated region (DMR) at their 5' exons. This DMR is commonly found in imprinted genes and correlates with transcript expression; one transcript produced from this locus and the antisense transcript are paternally expressed, noncoding RNAs, which may regulate regional imprinting. Alternative splicing of downstream exons results in different forms of the stimulatory G-protein alpha subunit, a key component of the classical signal-transduction pathway linking receptor-ligand interactions to adenylyl cyclase activation and various cellular responses.

Molecular pathology
GNAS mutations have been linked to pseudohypoparathyroidism types 1a and 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone and pituitary tumours.
References in periodicals archive ?
Ambassador-designate of Sri Lanka to the EU Grace Asirwatham had reportedly discussed details on the visit of the GSP Plus Monitoring Mission to Sri Lanka with European Commission Head of the South and South East Asia Division of the Directorate General of Trade (DG Trade) Peter Berz.
GSP Offshore SRL is a member of GSP Holding, a group of companies providing integrated services for the oil & gas industry, such as drilling, offshore construction, logistics, shipping engineering, aviation and training.
Aside from mayors of cities and municipalities, the DILG is enjoining all provincial governors and punong barangays to support the GSP by providing institutional support for the development of girl scouting in their communities.
The members of the GSP group agreed to buy 4,168 shares for $3 million in a deal that closed Jan.
In the meeting, GSP Deputy Director General, Yasimin Rizvi briefed the committee on the overall performance, number of employees and the challenging problems faced by the institution.
In 2018, US GSP imports from the Philippines stood at $1.73 billion, an increase of 15.57 percent from $1.49 billion in 2017.
"We're excited to have Frontier add additional flights to Denver for people traveling from the Upstate," Dave Edwards, GSP president and CEO, said in the release.
In a letter to the Speaker of the House of Representatives and the President of the Senate, the US President wrote: "In accordance with Section 502(f)(2) of the Trade Act of 1974, as amended (Trade Act) (19 U.S.C 2462(f)(2)), I am providing notice of my intent to terminate the designation of India as a beneficiary developing country under the Generalised System of Preferences (GSP) program."
The GSP is an autonomous instrument, which establishes terms of trade and which serves as a development policy, therefore trade preferences are not negotiated, but awarded, as standard terms of trade in European dealings with trade-partners and their representative country governments also known as beneficiary countries.
With India being the largest beneficiary of the GSP, it has been hit the most by the latest decision of the Trump administration.
Summary: With India being the largest beneficiary of the GSP, it has been hit the most by the latest decision of the Trump administration
1 -- The Trump administration is currently seriously reviewing the pros and cons of continuing the Generalized System of Preferences (GSP) to developing and less-developed countries in conformity with its disinterest in promoting democracy, rule of law and human rights overseas, the basis of GSPs objectives.