ADH5

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ADH5

A gene on chromosome 4q23 that encodes a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. ADH5 has minimal activity for ethanol oxidation, but has a high activity for oxidation of long-chain aliphatic alcohols and oxidation of S-(hydroxymethyl) glutathione. The ADH5 protein product is critical in metabolic elimination of formaldehyde, a potent irritant and sensitising agent that causes lacrymation, rhinitis, pharyngitis and contact dermatitis.
References in periodicals archive ?
Cellular levels of SNOs are controlled by the enzyme S-nitrosoglutathione reductase (GSNOR) through the process of de-nitrosylation (Malik et al., 2011).
N91115 works through a novel mechanism of action called S-nitrosoglutathione reductase (GSNOR) inhibition that is presumed to modulate the unstable and defective CFTR protein responsible for CF.
Pathophysiology is correlated with hypo- or hyper-S-nitrosylation of specific protein targets rather than a general cellular insult due to not only the loss of or enhanced nitric oxide synthase activity but also the denitrosylation by a major denitrosylase, S-nitrosoglutathione reductase (GSNOR) [1].
Liu, "S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis," Science Translational Medicine, vol.
The discovery of denitrosating enzymatic systems, namely, those dependent on thioredoxin 1 (Trxl) and S-nitrosoglutathione reductase (GSNOR) activities, which actively participate the S-nitrosothiol-to-sulfhydryl (SNO-to-SH) reduction [16-19] (Figure 1), definitively sealed the importance of S-nitrosation in cell physiology and human health (Table 1).
N6022, a first-in-class inhibitor of s-nitrosoglutathione reductase (GSNOR), has the potential to be an important new treatment for acute exacerbations of asthma, chronic obstructive pulmonary disease (COPD) and inflammatory bowel disease (IBD), the company said.