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A locus on chromosome 20q13.3 that has a highly complex imprinted expression pattern, giving rise to maternally, paternally and biallelically expressed transcripts derived from four alternative promoters and 5' exons. Some transcripts have a differentially methylated region (DMR) at their 5' exons. This DMR is commonly found in imprinted genes and correlates with transcript expression; one transcript produced from this locus and the antisense transcript are paternally expressed, noncoding RNAs, which may regulate regional imprinting. Alternative splicing of downstream exons results in different forms of the stimulatory G-protein alpha subunit, a key component of the classical signal-transduction pathway linking receptor-ligand interactions to adenylyl cyclase activation and various cellular responses.

Molecular pathology
GNAS mutations have been linked to pseudohypoparathyroidism types 1a and 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone and pituitary tumours.


Gerontological Society of America.
References in periodicals archive ?
The all-new features expanded information about Unnecto's dual SIM GSM phones, which enable callers to operate two cell phone plans (even from two providers) on a single device.
GSM Outdoors has built our reputation on quality products and on-time delivery from a team with an In It to Win It attitude.
The NetSurveyorWeb[TM] GSM system supports collection, decoding and storage of SMS data in plain textual formal in mass interception mode.
GPRS : GPRS (General Packet Radio Service) is a bearer service for GSM that greatly improved and simplified wireless access to packet data networks GPRS applies packet radio principal to transfer user data packets in an efficient way between MS (Mobile Station) and external packet data network [6].
The basis of the whole system is the GSM module in which the SIM card is placed.
- Cost savings with Least Cost Routing (LCR) - For calls between landline and GSM or between different GSM networks, which can be very expensive, the FreePBX dial plan can be configured with a prefix that, when dialed, will route calls placed from a SIP or analog telephone over a GSM trunk.
The acquisition means that Ericsson acquires an installed GSM base, expanding its North American footprint and strengthening the company's ability to provide a service to the region's operators.
According to the company, the Zynetix Ocean Linx is a GSM communications platform that features bandwidth conservation and an enhanced voice and text feature set.
Waitaki's GSM Total is harvested from one of the world's cleanest marine environments in New Zealand.
"However, if a CDMA network is installed, it requires less radio bases, so although the price might be higher the total cost of a CDMA network could be the same as GSM infrastructure."
In the third quarter 2004, GSM gained more customers than any other wireless technology in the Western Hemisphere by adding 13 million customers.
Just a month later, it ran at 2000 m/min producing higher basis weight tissue (17.5 gsm toilet tissue).