While other proteins (
GSK3B, POU5F1, MAPK14, CREB1, SOX2, KLF4, PRKACA, MAPK10, STAT1, ACTB, TUBB3, MYC, GAPDH, AKT1, and CTNNB1) are related with process of aging, neuronal diseases, cardiovascular diseases, abnormal brain development, mental retardation, schizophrenia, and mycobacterial and viral infections [60-62].
Akt, pAkt,
GSK3B, pGSK3B, and P13K were scored on a 3-point scale based on staining intensity: mild, moderate, and intense.
[5] Nonstandard abbreviations: miRNA or miR, microRNA; 3'-UTR, 3'-untranslated region; HIF, hypoxia-inducible factor; AR, androgen receptor; PI3K/Akt, phosphatidylinositol 3-kinase/RAC-alpha serine/threonine-protein kinase; CDK1B, cyclin-dependent kinase inhibitor 1B;
GSK3B, glycogen synthase kinase 3 beta; PTEN, phosphatase and tensin homolog; PSA, prostate-specific antigen; VHL, von Hippel-Lindau tumor suppressor; HIF1A, hypoxia inducible factor 1; VEGF, vascular endothelial growth factor; FGFR3, fibroblast growth factor receptor 3.
For example, both CE and insulin decreased the expression of
GSK3B, IGF1R, and 1GF2R [Fig.
Functional interaction of an axin homolog, conductin, with b-catenin, APC, and
GSK3b. Science.
This complex is necessary for the degradation of [beta]-catenin and is composed of three other proteins: glycogen synthase kinase 3 beta (
GSK3B), adenomatous polyposis coli (APC), and casein kinase I (CKI).
GSK3b phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21.
Zhai et al., "MAPT rs242562 and
GSK3B rs334558 are associated with Parkinson's disease in central China," BMC Neuroscience, vol.
De Sa Moreira et al., "Lithium reduces
Gsk3b mRNA levels: Implications for Alzheimer Disease," European Archives of Psychiatry and Clinical Neurosciences, vol.
identified many AD-related genes coregulating with App including
Gsk3b, Falz, Mef2a, Tlk2, Rtn, and Prkca [6].
Nine candidates failed the initial criteria, such as assay length or unsuitable CpG site location for primer and probe placement [BCOR, BCL6 co-repressor; CAV1, caveolin 1, caveolae protein, 22kDa; CD44, CD44 molecule (Indian blood group); CDH13, cadherin 13, H-cadherin (heart); VCAN (formerly CSPG2), versican; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32);
GSK3B, glycogen synthase kinase 3 beta; PCDH17, protocadherin 17; and TAF11, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa].
miR-21 silences PTEN and
GSK3b and reduces NF[kappa]B activity, which induces inflammation [46].
