GSK3B


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GSK3B

A gene on chromosome 3q13.3 that encodes a serine-threonine kinase of the glycogen synthase kinase subfamily, which is involved in glycogen metabolism, proliferation, motility, survival, neuronal development and body pattern formation.
 
Molecular pathology
GSK-3 plays a role in diabetes, cancer and neurologic disease—GSK3B polymorphisms are implicated in Parkinson disease; GSK3B overexpression may play a role in Alzheimer’s disease.
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While other proteins (GSK3B, POU5F1, MAPK14, CREB1, SOX2, KLF4, PRKACA, MAPK10, STAT1, ACTB, TUBB3, MYC, GAPDH, AKT1, and CTNNB1) are related with process of aging, neuronal diseases, cardiovascular diseases, abnormal brain development, mental retardation, schizophrenia, and mycobacterial and viral infections [60-62].
Akt, pAkt, GSK3B, pGSK3B, and P13K were scored on a 3-point scale based on staining intensity: mild, moderate, and intense.
[5] Nonstandard abbreviations: miRNA or miR, microRNA; 3'-UTR, 3'-untranslated region; HIF, hypoxia-inducible factor; AR, androgen receptor; PI3K/Akt, phosphatidylinositol 3-kinase/RAC-alpha serine/threonine-protein kinase; CDK1B, cyclin-dependent kinase inhibitor 1B; GSK3B, glycogen synthase kinase 3 beta; PTEN, phosphatase and tensin homolog; PSA, prostate-specific antigen; VHL, von Hippel-Lindau tumor suppressor; HIF1A, hypoxia inducible factor 1; VEGF, vascular endothelial growth factor; FGFR3, fibroblast growth factor receptor 3.
For example, both CE and insulin decreased the expression of GSK3B, IGF1R, and 1GF2R [Fig.
Functional interaction of an axin homolog, conductin, with b-catenin, APC, and GSK3b. Science.
This complex is necessary for the degradation of [beta]-catenin and is composed of three other proteins: glycogen synthase kinase 3 beta (GSK3B), adenomatous polyposis coli (APC), and casein kinase I (CKI).
Zhai et al., "MAPT rs242562 and GSK3B rs334558 are associated with Parkinson's disease in central China," BMC Neuroscience, vol.
De Sa Moreira et al., "Lithium reduces Gsk3b mRNA levels: Implications for Alzheimer Disease," European Archives of Psychiatry and Clinical Neurosciences, vol.
identified many AD-related genes coregulating with App including Gsk3b, Falz, Mef2a, Tlk2, Rtn, and Prkca [6].
Nine candidates failed the initial criteria, such as assay length or unsuitable CpG site location for primer and probe placement [BCOR, BCL6 co-repressor; CAV1, caveolin 1, caveolae protein, 22kDa; CD44, CD44 molecule (Indian blood group); CDH13, cadherin 13, H-cadherin (heart); VCAN (formerly CSPG2), versican; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); GSK3B, glycogen synthase kinase 3 beta; PCDH17, protocadherin 17; and TAF11, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa].
miR-21 silences PTEN and GSK3b and reduces NF[kappa]B activity, which induces inflammation [46].