GSK3A


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GSK3A

A gene on chromosome 19q13.2 that encodes a multifunctional protein serine kinase, which participates in the control of various regulatory proteins, including glycogen synthase and transcription factors (e.g., JUN, and plays a role in the WNT and PI3K signalling pathways.
References in periodicals archive ?
In our current study, livers from [LDLR.sup.-/-]; [macLRP1.sup.-/-] mice fed a Western diet for eight weeks had significantly lower levels of phosphorylated GSK3[alpha] (Ser21) compared to [LDLR.sup.-/-] littermates, suggesting higher levels of GSK3a activity; however, we did not observe any differences in GSK3[beta] phosphorylation at Tyr216, which is essential for kinase activity.
Circled bands are specific for GSK3a (1), GSK3[beta] (2), and p38 MAPK (3).
GSK-3 was inactivated by phosphorylation of serine 9 in GSK-3[beta] and serine 21 in GSK3a [18]; Akt appears to be the predominant kinase mediating this phosphorylation of GSK-3.