GSA


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GNAS

A locus on chromosome 20q13.3 that has a highly complex imprinted expression pattern, giving rise to maternally, paternally and biallelically expressed transcripts derived from four alternative promoters and 5' exons. Some transcripts have a differentially methylated region (DMR) at their 5' exons. This DMR is commonly found in imprinted genes and correlates with transcript expression; one transcript produced from this locus and the antisense transcript are paternally expressed, noncoding RNAs, which may regulate regional imprinting. Alternative splicing of downstream exons results in different forms of the stimulatory G-protein alpha subunit, a key component of the classical signal-transduction pathway linking receptor-ligand interactions to adenylyl cyclase activation and various cellular responses.

Molecular pathology
GNAS mutations have been linked to pseudohypoparathyroidism types 1a and 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone and pituitary tumours.

GSA

Gerontological Society of America.
References in periodicals archive ?
While DLA and GSA had a less than ideal working relationship in the early 1960s, time, complementary goals and experience working together improved relations by the late 1970s.
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Wichita North High School GSA, (316) 204-5621, kellykk00@yahoo.com, rhorning@usd259.net, cwidmer@ usd259.net, meets every Wednesday at lunch in room A213.
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The Navy announced updates to the Individual Augmentee Manpower Management (IAMM) and Global War on Terrorism Support Assignment (GSA) programs, the two programs used for manning the Navy's joint manning doctrine requirements.
Over the next year, MOTSU worked in coordination with the Army Corps of Engineers, Savannah District, to prepare the necessary documentation to turn the property over to the General Services Administration (GSA) for final disposition.