GRIP1


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GRIP1

A gene on chromosome 12q13.13 that encodes a protein which is thought to play a role as a localized scaffold for assembling a multiprotein signalling complex and mediating trafficking of its binding partners at specific subcellular sites in neurons.
GRIP1 interacts with EFNB1, EFNB3, EPHA7, EPHB2, FRAS1, GRIA2, GRIA3, GRIPAP1/GRASP1, KIF5A, KIF5B, KIF5C, PLCD4, PPFIA1, PPFIA4, PRLHR, PTPRF, SLC30A9 and liprins-alpha. GRIP1 can form homomultimers or heteromultimers with GRIP2, and a ternary complex with GRIA2 and CSPG4. It interacts with ATAD1 in an ATP-dependent manner—ATAD1-catalysed ATP hydrolysis disrupts binding to ATAD1 and to GRIA2 and leads to AMPAR complex disassembly.
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Where, [Y.sub.ijklmn] is the measured phenotype; [mu] is the population mean, [S.sub.i] is the fixed effect of ith sex, [B.sub.j] is the fixed effect of jth batch, [P.sub.k] is the fixed effect of kth parity, [G.sub.l] is the fixed effect of lth genotype of GRIP1, [b.sub.1] is a regression coefficient, [CW.sub.ijklm] is the covariate for the carcass weight, [A.sub.ijklm] is the random additive polygenic animal effect and [[epsilon].sub.ijklm] is the random residual effect.
In order to estimate the additive and dominance coefficients of each SNP found in GRIP1, [G.sub.l] in the Model 1 was replaced by additive variable [X.sub.additive] (coded as 1 for rare allele homozygote, -1 for common allele homozygote, and 0 for heterozygote), and dominance variable [X.sub.dominance] (coded as 0 for two homozygotes, 1 for heterozygote).
NCOA2, also known as GRIP1, interacts with the five steroid hormone receptor types (Hong et al.