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GRIP1A gene on chromosome 12q13.13 that encodes a protein which is thought to play a role as a localized scaffold for assembling a multiprotein signalling complex and mediating trafficking of its binding partners at specific subcellular sites in neurons.
GRIP1 interacts with EFNB1, EFNB3, EPHA7, EPHB2, FRAS1, GRIA2, GRIA3, GRIPAP1/GRASP1, KIF5A, KIF5B, KIF5C, PLCD4, PPFIA1, PPFIA4, PRLHR, PTPRF, SLC30A9 and liprins-alpha. GRIP1 can form homomultimers or heteromultimers with GRIP2, and a ternary complex with GRIA2 and CSPG4. It interacts with ATAD1 in an ATP-dependent manner—ATAD1-catalysed ATP hydrolysis disrupts binding to ATAD1 and to GRIA2 and leads to AMPAR complex disassembly.
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