GRIN2D

GRIN2D

A gene on chromosome 19q13.33 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN2D forms a complex with GRIN1, GRIN3A or GRIN3B; it interacts with PDZ domains of INADL and DLG4.
References in periodicals archive ?
They found that expression levels of the NMDA receptor genes GRIN1, GRIN2A, and GRIN2D increased following cell cultures exposed to alcohol for 7 days.
Table 3 Potential Pharmacogenetic Targets Detected in Human Postmortem Brain Studies in Alcohol-Dependent Subjects and Animal Studies Potential Altered Genes (Reference) Medication Targets Human Postmortem Studies Animal Studies Acamproate ([up arrow]) NMDA subunit ([down arrow]) GRIN1 with genes GRIN2B and GRIN2D chronic ethanol use in in hippocampus (Enoch et dorsolateral prefrontal al.