GRIN2B

GRIN2B

A gene on chromosome 12p12 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN2B forms a complex with GRIN1, GRIN3A and PPP2CB; it interacts with HIP1, NETO1, MAGI3 and DAPK1, and with the PDZ domains of INADL and DLG4. It is highly expressed in the fronto-parieto-temporal cortex and hippocampus pyramidal cells.

Molecular pathology
Defects in GRIN2B cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
Another gene identified in this group, GRIN2B, encodes a subunit of a receptor that has roles in resilience of neurons and memory.
This view has been corroborated by a number of studies that found GRIN2B to be implicated in phenotypes associated with rewards-related and impulsive behaviour such as smoking initiation (Vinik et al, 2009), alcoholism (Wernicke et al, 2003), pathological gambling (Lee et al, 2009), and obsessive-compulsive disorder (OCD [Arnold et al, 2009]).
Similarly, a study conducted by Ness, Arning, Stuttgen, Epplen & Beste (2011) found that variations in GRIN2B (N-methyl-D-aspartate receptor 2B subunit) gene may contribute towards risky decision-making with respect to NMDAR (N-methyl-D-aspartate receptor) mechanisms.
In the light of the nature-nurture debate, it would appear that GRIN2B may play a significant role in the process of reward-seeking behaviour which is also involved in the process of risky decision making.
Association of DRD3 and GRIN2B with impulse control and related behaviours in Parkinson's disease.
Table 3 Potential Pharmacogenetic Targets Detected in Human Postmortem Brain Studies in Alcohol-Dependent Subjects and Animal Studies Potential Altered Genes (Reference) Medication Targets Human Postmortem Studies Animal Studies Acamproate ([up arrow]) NMDA subunit ([down arrow]) GRIN1 with genes GRIN2B and GRIN2D chronic ethanol use in in hippocampus (Enoch et dorsolateral prefrontal al.
Six loci (DAPK, HOXA1, CRABP1, TWIST1, GRIN2B, and TIMP3) showed statistically higher methylation levels in adult samples than in pediatric samples (all values, P < .
Among them, GO:0004888 dominantly contains 33 transcripts encoding signal receptors, and these receptors could be further classified into several subgroups: OXTR, LOC431251 and SSTR3 belong to reproductive hormone receptors; CHRM2, ADRA2B, P2RX4, P2RY2, EDNRB2, GABRB2, GABRG2, LOC428961 and NPFFR2 function as receptors mediating neurotransmitters or neuropeptide; GRIN2B and GRIN3A could modulate the efficiency of synaptic transmission; NTRK1 and NTRK2 belong to the receptor tyrosine kinase (RTK) family, and are involved with neurotrophin (GO:0005030--neurotrophin receptor activity; and GO:0043121--neurotrophin binding) (Table 5).
CXCL12, C5 Tachycardia Imipramine GRIN2B, ADORA3, KCNH7, CHRNA7, KCNG2, KCNQ1, CHRNA5, ADORA1, CASQ2, ADRA1B, ADRB3, ADRA1D Kidney failure Imipramine EPO, ALB, EDNRA, FKBP1A, NR3C2, VDR, PPP3CA Glomerular injury EtOH-Fr SREBF1 Cardiac congestive Cardiac failure Imipramine EPO, NOS1.