GRIN1

GRIN1

A gene on chromosome 9q34.3 that encodes the zeta subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in the plasticity of synapses (central to memory and learning).

Molecular pathology
Defects in GRIN1 cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
GRIN1, which encodes the essential glutamate (NMDA) receptor subunit C-1 (Monyer et al.
They found that expression levels of the NMDA receptor genes GRIN1, GRIN2A, and GRIN2D increased following cell cultures exposed to alcohol for 7 days.
Table 3 Potential Pharmacogenetic Targets Detected in Human Postmortem Brain Studies in Alcohol-Dependent Subjects and Animal Studies Potential Altered Genes (Reference) Medication Targets Human Postmortem Studies Animal Studies Acamproate ([up arrow]) NMDA subunit ([down arrow]) GRIN1 with genes GRIN2B and GRIN2D chronic ethanol use in in hippocampus (Enoch et dorsolateral prefrontal al.
Previa extraccion del ADN genomico de 200 [micron]l de sangre completa, con el kit Qiagen DNA Minikit (QIAGEN), se determinaron mediante reaccion en cadena de la polimerasa (PCR) en tiempo real los SNP seleccionados de los genes ABCB1 (rs1045642), CYP2B6 (rs3745274), OPRM1 (rs1799971), ARRB2 (rs3786047, rs2036657 y rs1045280), DfiH (rs1611115), GRIN1 (rs6293, rs4880215 y rs2301364) y POR (rs1057868, rs28931608 y rs28931608).
Se hallaron asociaciones significativas entre los polimorfismos rs2301364 del gen GRIN1 y concentraciones sanguineas de S-imc (CC + CT, 4,9 [+ o -] 2,2 frente a TT, 3,8 [+ o -] 2,2; p = 0,043), y entre el rs3786047del gen ARRB2 y R-imc (TT, 5,5 [+ o -] 2 frente aCC + CT, 3,9 [+ o -] 2; p = 0,032); no obstante, tales asociaciones dejan de ser significativas con la correccion de Bonferroni para multiples tests.
Transliminality, and its constituent characteristics, should be associated with overlapping polygenic sets of genetic loci and gene polymorphisms implicated in corpus callosum neurodevelopment and schizophrenia spectrum vulnerability, possibly including COMT, DISC1, GRIN1, and BDNF genes.
El gen GRIN1 codifica la subunidad NR1, que es un componente principal para la funcionalidad del receptor.