GRIA4

GRIA4

A gene on chromosome 11q22 that encodes a member of the excitatory neurotransmitter glutamate receptor family, which are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and function as ligand-activated cation channels.

Molecular pathology
Weak data have linked GRIA4 mutations to schizophrenia.
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(1) In short, Gene Ontology analysis has identified several potentially affected pathways involved in synaptic transmission (HTR2A, BDNF, CHRNA3, CHRNB4, DRD1, DRD2, DRD4, EGR1, GRIA4, GRIN2B, GRM3, NISCH, SLC1A3, and ERBB4), dopamine metabolic processes (COMT, DRD1, DRD2, DRD4, MAOA, NR4A2, and SLC6A3), and ion channel activity (CHRNA7, CACNA1I, CACNB2, CHRNA3, CHRNA5, CHRNB4, GABRB3, GRIA4, GRIA1, GRIN2B, HCN1, CACNA1C, KCTD13, KCNV1, KCNN3, KCNJ13, and KCNB1).
However, several unsuccessful genetic studies in humans have been developed to associate different SNPs in the AMPAR subunits, GluR1, GluR2, and GluR4 (encoded by the GRIA1, GRIA2, and GRIA4 genes, resp.), with SCZ [146], BPD [148], and major depressive disorder [149].
De Ronchi et al., "Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia," Neuroscience Letters, vol.
A recent study of OSCC tumors from German OSCC patients suggests that ALH1A2, OSR2, GATA4, GRIA4, and IRX4 gene transcription is regulated by gene-promoter hypermethylation, which in turn correlates with HPV status in OSCC tumors (22).
Topiramate ([up arrow]) GRIA4 and GRIA2 flop mRNA levels in GRIK3 in hippocampus OFC and GRIA3 flip and (Enoch et al.
(29) A recent GWAS (30) found that a combination of 6 genetic mark-ers--NPAS3, XKR4, TNR, GRIA4, GFRA2, and NUDT9P1--predicted treatment response to iloperidone.