These genes and the potential function of the proteins they encode are summarized in Table 5 and include those for glypican 5 (GPC5) collagen type XXV alpha-1, hyaluronan proteoglycan link protein, calpastatin, and neuronal PAS domain protein 3 ; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GRIA3
, type 1 IFN-related proteins ADAR and IFNAR2, cell cycle-dependent protein CIT, zinc finger proteins ZFAT and ZFHX4, and guanosine triphosphatase-activating protein STARD13 ; SLC9A9, an [Na.sup.+]/[H.sup.+] exchanger found in endosomes ; NINJ2, TBXAS1, and genes related to the glutamatergic system (GRM3 and GRIK2) ; and FHIT (fragile histidine triad) and GAPVD1 (GTPase-activating protein and VPS9 domains 1) .
Disease or Function p-Value Molecules # Mole Annotation cules Mood disorders 3.73E--04 ADRA2B, ALOX12, AQP4, CA9, 22 CACNB2, CCKBR, CHRNA1, CHR NB4, CHRNG, DDC, ESR1, GRIA3
, GRIK2, GRIN1, KCNK2, MTNR 1A, MYOM1, NCAM1, NDUFS7, PDE11A, SCN11A, SCN2B Depressive disorder 7.90E--04 ADRA2B, AQP4, CACNB2, 14 CCKBR, CHRNA1, CHRNB4, CHRNG, ESR1, GRIA3
, GRIN1, KCNK2, MYOM1, NCAM1, PDE11A Table 3 Effect of Rhodiola on genes involved in depression ([section]).
These targets included genes for multiple neurotransmitter receptors (GRIA3
, GRM3, and GABRR2), PCLO [piccolo (presynaptic cytomatrix protein)], and NTRK2 (neurotrophic tyrosine kinase, receptor, type 2).