GRB10


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GRB10

A gene on chromosome 7p12.2 that encodes an adapter protein which binds to, and suppresses signals from, activated receptors tyrosine kinases—e.g., insulin and insulin-like growth factor receptors (INSR and IGF1R, respectively)—by either interfering with the signalling pathway or increasing receptor degradation. It also downregulates Wnt signalling by interfering with the binding of AXIN1 to LRP6, and it may inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB10 upregulates the KDR/VEGFR-2 signalling pathway.
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References in periodicals archive ?
From that prior analysis, 442 epigenetic loci were identified that were [+ or -] 1,500 bp of the start and end coordinates for DLX5, H19, IGF2, IGF2-AS, NDN, CPA4, GRB10, ILK, and THSD7A, which had been assessed for associations between placental Cd and DNA methylation.
We identified Cd-associated variations in the expression of six imprinted genes, DLX5, H19, NDN, IGF2-AS, IGF2, and THSD7A across studies and within both sexes, as well as sex-specific associations for CPA4, GRB10, and ILK.
Heller, "The TORC1-activated proteins, p70S6K and GRB10, regulate IL-4 signaling and M2 macrophage polarization by modulating phosphorylation of insulin receptor substrate-2," Journal of Biological Chemistry, vol.
Studies performed in HeLa human cell line, using small interfering (si)RNA, revealed that knockdown of Grb10 gene enhances IGF-I DNA synthesis by activating Akt/PKB (also called protein kinase B) and ERK1/2 (DUFRESNE & SMITH, 2005).
To date, the presence of the Grb10 mRNA and protein have not been investigated in mammalian oocytes, despite the importance of growth factors that bind receptors with tyrosine kinase activity during mammalian oocyte molecular maturation.
The first of these additional hyperhydroxymethylated genes, Grb10, encodes the growth factor receptor-bound protein 10 (Grb10).
miR type Animal model miR33 STZ-induced diabetic Ldlr-/- mice miR125b Type 2 diabetic db/db mice miR 200 Type 2 diabetic db/db mice miR 504 Type 2 diabetic db/db mice miR138 Type 2 diabetic db/db mice miR type Mechanism miR33 Increased macrophages and lipid content miR125b Increased inflammatory gene expression miR 200 Increased inflammatory gene expression miR 504 Vascular smooth muscle phenotype change miR138 Vascular smooth muscle phenotype change miR type Target gene Reference miR33 ABCA1 [37] miR125b SUV39H1 [38] miR 200 Zeb1 [39] miR 504 Grb10 [40] miR138 SIRT1 [41] ABCA1: ATP-binding cassette transporter A1; SIRT1: silent information regulator 1.
Grb10 seems to have a significant role in promoting muscle growth without any change in activity, diet, or adverse health effects, according to researchers.
The list of the gene names and their abbreviation were: Calcitonin receptor (CALCR), growth factor receptor-bound protein 10 (Grb10), 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A), potassium channel, subfamily K, member 9 (KCNK9), potassium voltage-gated channel, subfamily Q, member 1 (Kcnq1), mesoderm specific transcript homolog (MEST), oxysterol binding protein-like 5 (OSBPL5), protein phosphatase 1, regulatory (inhibitor) subunit 9A (PPP1R9A), sarcoglycan, epsilon (Sgce), solute carrier family 22, member 18 (SLC22A18), and ubiquitin protein ligase E3A (UBE3A).
Of the 15 maternally methylated germline ICRs, four (IGF2R, KvDMR, SNURF/SNRPN, GNASXL) overlapped Cd-associated DMRs in newborn cord blood, nine (SNURF/SNRPN, GNASXL, PEG3, MCTS2, NNAT, GNAS, PLAGL1, GRB10, PEG13) overlapped DMRs in maternal blood, and four did not overlap with DMRs in either newborn cord blood or maternal blood (Figure 2A).
Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.
We studied a total of 6 loci in the 4 ICRs of GRB10 (growth factor receptor-bound protein 10) (7p14), MEST(7q32), HI9, and KCNQIOTI (11p15.5) via digestion with the methylation-sensitive 4-base cutter HpaII and the methylation-sensitive rare-cutter NotI (Table 1).