GZMB

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GZMB

A gene on chromosome 14q11.2 that encodes an enzyme necessary for target cell lysis in cell-mediated immune responses, and which is linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis. GZMB cleaves caspase-3, -7, -9 and -10, activating enzymes that mediate apoptosis.
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References in periodicals archive ?
The fact that all 3 of these GRB-neutrino candidates were detected sizably in advance of the triggers of the GRBs they could be associated with is not particularly significant from the standard perspective of this sort of analysis, and actually obstructs any such attempt to view them as GRB neutrinos: no current GRB model suggests that neutrinos could be emitted thousands of seconds before a GRB.
Caption: Figure 18: The death of a massive star produces a GRB (and its multiband AG) and an energetic and bright SN (from [439]).
The aim of our study is to assess the extent to which this potential is effectively realised and to explore the mechanisms through which GRB works.
GRB 130925A, by contrast, produced gamma rays for 1.9 hours, more than a hundred times greater than a typical long GRB.
As with muscadine grapes, our study suggests that the application of chlorpyrifos would be best timed after harvest and slightly after the peak GRB emergence for that area.
GRB has just promoted Marielle Zuccarelli to director of international sales as the company accelerates its global efforts.
Until now, astronomers have been unable to study the earliest moments in the development of a supernova of this kind (a GRB-SN), but SN2017iuk was fortuitously close-by -- at roughly 500 million light years from Earth -- and the GRB light was underluminous, allowing the SN itself to be detectable at early times.
"It was apparently diverted to GRB because of bad weather," the airport wrote on (https://www.facebook.com/austinstraubelairport/photos/a.176367478502.122596.170879178502/10155979343433503/?type=3&theater) Facebook .
In 2015, GRB continues to lead the way with boundary-pushing, provocative programming, including Sex Sent Me to the ER for TLC, Outrageous Births: Tales from the Crib and Diagnose Me for Discovery Life Channel, Twisted Tales of My 9 to 5 for Investigation Discovery, and #redflag, a groundbreaking television event co-produced with Kim Kardashian, for HLN.
Spectral-Lag Relation in GRB Pulses Detected with HETE-2, Astronomical Society of Japan 62, 487-499, 2010.
Caption: Figura 1: Esquema geral para um GRB, longo ou curto, dentro de um diagrama do tipo espaco-tempo.
If this scenario holds up, GW170817 could mark an entirely new class of GRBs. But the debate rages on: Several papers in the pipeline argue that a successful, off-axis jet can better explain the latest data, returning this event to its status as a typical short GRB.