GP6

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GP6

A gene on chromosome 19q13.4 that encodes a 58-kD platelet membrane glycoprotein, which plays a central role in the collagen-induced platelet activation and aggregation. Injury to the vessel wall and damage to the endothelial lining exposes the subendothelial matrix to blood flow, resulting in deposition of platelets. Collagen, especially types I, III and VI, are the most thrombogenic macromolecules of the extracellular matrix. The adhesion of platelets to collagen results in activation, leading to platelet secretion, recruitment of additional platelets and aggregation resulting in a platelet plug, which limits blood loss. However, collagen exposure after rupture of atherosclerotic plaques results in thrombus formation and may lead to myocardial infarction or stroke.
References in periodicals archive ?
Therefore, the relevance and frequency of innate issues of GPVI remain low.
Platelet-collagen interaction: is GPVI the central receptor?
Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS).
GPVI down regulation in murine platelets through metalloproteinase-dependent shedding.
Differentially regulated GPVI ectodomain shedding by multiple plateletexpressed proteinases.
By sequence homology, GPVI is a member of the immunoglobulin superfamily, and its sequence is closely related to Fc[alpha]R and the natural killer receptors.
In the initial characterizations of platelet GPVI function, some degree of heterogeneity was noted among apparently normal subjects.
To specifically investigate this potential heterogeneity, we developed a semiquantitative ligand blot assay, in which biotin-conjugated convulxin binds selectively to GPVI among the total content of platelet proteins separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
At this time, however, a genetic basis for variation in GPVI content has not been defined.
Finally, as recently reported by Nieswandt et al, (65) GPVI might be a potential therapeutic target for prophylaxis of ischemic heart disease.