OXGR1

(redirected from GPR99)

OXGR1

A gene on chromosome 13q32.1 that encodes an orphan G protein-coupled receptor for alpha-ketoglutarate, which appears to act exclusively by a G(q)-mediated pathway.
References in periodicals archive ?
GPR17 and GPR99, recently identified, may also be additional receptors for LTD4/LTC4 [11] and LTE4, respectively [12]; moreover, LTE4 has been reported to upregulate COX-2 through the PPAR[gamma] receptor in mast cells [13], as well as to bind the P2Y12 receptors [14].
Aforementioned, the CysLTs exert their effects by binding to G-protein-coupled receptors [CysLT.sub.1]R and [CysLT.sub.2]R and novels GPR99 [12] and GPR17 [11].
GPR91, a member of GPCR family, serves as the ligand for succinate, while another member (GPR99) is the ligand for [alpha]-ketoglutarate.
Indeed, these receptors are phylogenetically related to purinergic P2Y class of GPCRs [4] and evidence reported in the literature suggests the existence of additional receptors responding to CysLTs [5], such as GPR17 [6], GPR99 [7], PPARy [8], P2Y6 [9], and P2Y12 [10].
Yoshimoto et al., "Leukotriene E 4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99," Proceedings of the National Academy of Sciences, vol.