HCAR1

(redirected from GPR81)

HCAR1

A gene on chromosome 12q24.31 that encodes a G protein-coupled receptor for L-lactate, which mediates its anti-lipolytic effect via a G(i)-protein-mediated pathway.

References in periodicals archive ?

LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B)," Pharmacological Reviews, vol.

Potential Synergies of [beta]-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health

Lactate inhibits lipolysis in fat cells through activation of an orphan g-protein-coupled receptor, GPR81. J Biol Chem.

Exercise is medicine: vascular occlusion training for muscle growth

Interestingly, a lactate receptor called GPR81 was recently isolated in rats, confirming that it does indeed act like a hormone.

New perspectives on lactate and lactic acid

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