GPR81 | definition of GPR81 by Medical dictionary
HCAR1 (redirected from GPR81)
HCAR1 A gene on chromosome 12q24.31 that encodes a G protein-coupled receptor for L-lactate, which mediates its anti-lipolytic effect via a G(i)-protein-mediated pathway.
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References in periodicals archive
LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81
, GPR109A, and GPR109B)," Pharmacological Reviews, vol.
Lactate inhibits lipolysis in fat cells through activation of an orphan g-protein-coupled receptor, GPR81
. J Biol Chem.
Interestingly, a lactate receptor called GPR81
was recently isolated in rats, confirming that it does indeed act like a hormone.