GPR77 | definition of GPR77 by Medical dictionary
GPR77 A gene on chromosome 19q13.33 that encodes a G protein-coupled receptor for the chemotactic and inflammatory peptide anaphylatoxins C5a, C4a and C3a and their derivatives.
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References in periodicals archive
The complement activation product C5a interacts not only with PMN via abundantly expressed specific receptors (C5aR1 = CD88 and C5aR2 = C5L2 = GPR77
) [5, 6] but also with other immune cells and epithelial cells .
In 2000 and 2001, the human C5aR2 gene (also named GPR77
or C5L2, C5a-like receptor 2) was cloned by two independent research groups [10, 11].
C5L2 primers were purchased from Qiagen (GPR77
: QT00243971, QuantiTect Primer Assay, Qiagen, Mississauga, ON).