GPR68

GPR68

A gene on chromosome 14q31 that encodes a proton-sensing receptor involved in pH homeostasis, which mediates its action by association with G proteins, stimulating inositol phosphate production or Ca2+ mobilisation.
References in periodicals archive ?
identified a candidate gene GPR68, whose expression products has been implicated in calcium metabolism, for modulating the sensitivity to LEN in MDS cells.
Recent studies suggest that OGR1-family GPCRs, including OGR1 (GPR68), GPR4, and T cell-death associated gene 8 (TDAG8 or GPR65), also sense extracellular protons and, thereby, stimulates a variety of cellular activities through several types of G proteins [18-21] (Figure 1).
Tiegs et al., "The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH," British Journal of Pharmacology, vol.