Cannabinoid receptors, including C[B.sub.1], C[B.sub.2], GPR55
, PPAR[alpha], and PPAR[gamma], have been found on human articular cartilage from patients with symptomatic osteoarthritis (OA).
In contrast to delta-9-THC, CBD has low affinity for CB1 and CB2 receptors, but anticonvulsant properties are linked to regulation of voltage gated potassium and sodium channels, and GPR55
as senior scientist with Cannabics Pharmaceuticals Inc., a Bethesda-based firm that develops cannabinoid diagnostic tests for the personalized treatment of cancer.<br />The two new team members will support Cannabics' data-discovery process with the goal of identifying new cannabinoid diagnostic tests and treatments for cancer.<br />Sharir is widely recognized for her role in identifying a potentially new cannabinoid receptor, GPR55
. She was a member of a research group responsible for discovering that human GPR55
is activated by several types of cannabinoids.
evaluated the activity of the cannabinoid receptor G Protein-coupled Receptor 55 (GPR55
) and its ligands O-1602 in the gut movement of rodents with lipopolysaccharide (LPS)-induced intestinal inflammatory disease and concluded that CBD selectively normalizes motility perturbation through potential mechanisms involving systemic anti-inflammatory effect and regulation of the myoelectrical activity in the intestine (39).
The orphan receptor GPR55
is a novel cannabinoid receptor.
They also affect the receptor attached to proteins G 55 (GPR55
), which is codified by the gene HGNC, situated on chromosome 2 (Palkovits et al., 2008).
Interestingly, cg01610636 in PLVAP (chromosome 19) encoding plasmalemma vesicle associated protein, as well as cg21022949 located 19.7 kbp downstream of G-protein-coupled receptor 55 (GPR55
, chromosome 2) appeared to be FDR-significant after cell-type correction (p = 7.0 x [10.sup.-7] and p = 8.9 x [10.sup.-7] corrected and p = 0.002 and 1.5 x [10.sup.-5] uncorrected, respectively).
Fernandez-Suarez et al., "GPR55
: A therapeutic target for Parkinson's disease?" Neuropharmacology, vol.
They participate in cell signaling and are ligands for transmembrane receptors (mainly CB1/2 but also VR1 and GPR55
); activation of CB1 is responsible for oxidative stress formation, whereas CB2 prevents ROS generation [7, 8].
Moreover, the G proteincoupled receptor 55 (GPR55
) and G protein-coupled receptor 119 (GPR119) are currently being postulated as new members of the cannabinoid receptor family (47) as they have recently been identified as being targets for the endocannabinoids.
(19-21) Also, other studies suggest that cannabinoids may exert therapeutic their effects by targeting [alpha]3 glycine receptors, stimulating PPAR[gamma] receptor activity, increasing intracellular [Ca.sup.2] and antagonizing GPR55
This compound acts through multiple pharmacological targets, including facilitation of the endocannabinoid system, activation of transient receptor potential vanilloid type 1 (TRPV1) channel, the peroxisome proliferator-activated receptor [gamma] (PPARy), GPR55
, 5-hydroxytryptamine receptor subtype 1A (5-[HT.sub.1A]), the adenosine membrane transporter phospholipase A2, lipoxygenase (LOX) and cyclooxygenase 2 (COX-2) enzymes, and [Ca.sup.2+] homeostasis .