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Small Molecule to Target GPR50 for CNS and Metabolic Disorders - Drug Profile 82
Another interesting observation that could result in future basis for the understanding of melatoninergic drugs effects in health and disease is the dimerization of melatonin receptors with G protein-coupled receptor 50 (GPR50).
Migaud et al., "GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals," BMC Evolutionary Biology, vol.
They're re-badged versions of existing Derbis ( the RS like the GPR50, and the other two taking after their Senda equivalents.
p53-independent benzene-induced decrease or increase Decrease CR6, EGFBP-1, GDIA, GDI-alpha, mGk-6, Glut-3, HDGF, PKD1, ZO-1 WT: decreased p53-KO: decreased Increase ALK-1, Angrp, cardiac troponin T, Ctsg, CYP2E1, Dmp1, Fmo3, WT: increased fra-2, GHR, Gpr50, Hox-1.7, KIK-I, MPO, NEFA protein, NrLi1, p53-KO: increased Nsg-1, PN-1, RAB17, Sim1, Sox10, Tip30, TNFRrp, WBP9 B.
8:15 The Involvement of Mutations in GPR50 in X-Linked Mental Retardation.
The purpose of this research then is to explore GPR50, a gene located in chromosomal region Xq28, for its possible involvement in X-Linked Mental Retardation (XLMR).
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