LGR5

(redirected from GPR49)

LGR5

A gene on chromosome 12q22-q23 that encodes an orphan G protein-coupled receptor that is the stem cell marker of the intestinal epithelium and hair follicles. LGR5 is the target gene of Wnt signalling.
References in periodicals archive ?
Glutamine synthase and GPR49, a G-protein-coupled orphan nuclear receptor, are 2 proteins whose expression is activated by [beta]-catenin in hepatocellular carcinomas and, as such, may serve as reliable markers of [beta]-catenin activation.
To more accurately discriminate between the 4 classes of hepatic adenomas, Bioulac-Sage and colleagues tested a panel of markers including L-FABP1 (liver fatty acid binding protein) and UGT2B7, targets of activation by HNF1[alpha]; glutamine synthase and GPR49, targets of activation by [beta]-catenin; and the acute phase reactants serum amyloid A2 and C-reactive protein.
Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with betacatenin mutations.