FFAR3

(redirected from GPR41)

FFAR3

A gene on chromosome 19q13.1 that encodes a receptor for short-chain free fatty acids, the activity of which is coupled to the formation of inositol 1,4,5-trisphosphate, intracellular Ca2+ mobilisation, the activation of ERK 1/2 and inhibition of intracellular cAMP
accumulation.
References in periodicals archive ?
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).
In the last decades, several G-protein coupled receptors (GPCRs), i.e., GPR40, GPR41, GPR43, GPR84, and GPR120, were deorphaned as free fatty acids (FFAs) receptors [1-5].
It has been elucidated that SCFAs activate GPR41 and GPR43 and thus regulate the secretion of enteroendocrine peptides [61-63].
Ding, "GPR41 and GPR43 in obesity and inflammation - protective or causative?," Frontiers in Immunology, vol.
Known as two formerly orphan G protein-coupled receptors, GPR41 is found in a wide range of tissues including neutrophils, while GPR43 is shown to be highly expressed in immune cells [40].
Two G-protein-coupled receptors identified as receptors for SCFA are free fatty acid receptor 2 (FFA2) and FFA3, also known as GPR43 and GPR41, respectively.
Kimura et al., "Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-[alpha]-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells," Biochemical and Biophysical Research Communications, vol.
Se sugiere que los AGCC son productos bacterianos claves para promover la integridad intestinal, aunque no es claro si este efecto se da por la inhibicion de la histona deacetilasas (HDACs, por la sigla en ingles de histone deacetylases) o por la estimulacion de receptores acoplados de la proteina-G (GPCRs, de su sigla en ingles G-protein-coupled receptors) GPR41, GPR43 o GPR109 (32).
Significant increases in the expression of the G-protein-coupled receptors (Gpr41 and Gpr43) were found in the colons of TCDF-treated mice (see Supplemental Material, Figure S10A).
At least three GPCRs have been identified that bind to short chain fatty acids (SCFAs) produced by gut bacteria: GPR41, GPR43, and GPR109A.
Another gene, Gpr41, with a non-odor-related receptor, had the opposite effect.
The SCFA propionate modulates energy homeostasis by promoting GPR41 (G protein-coupled receptor 41)-mediated activation of sympathetic neurons, in contrast to ketone bodies (47).