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It mediates its action by acting on a G-protein-related orphan receptor 39 (GPR39) which belongs to ghrelin receptor subfamily.
Changes in obestatin gene and gpr39 receptor expression in peripheral tissues of rat models of obesity, type 1 and type 2 diabetes.
The study modified the levels of the protein encoded by a single gene - GPR39 - which is a zinc-binding receptor previously associated with depression.
Using a commercially available substance that mimics the activity of the GPR39 protein, the researchers found that targeting this gene dramatically reduced alcohol consumption in mice.
Particular attention will be paid to the recently described zinc-sensing GPR39 receptor  and aspects of zinc deficiency.
Also mice lacking the GPR39 receptor, a G protein-coupled receptor, which is activated by zinc [8, 32], display depressive-like behavior .
El GHS-R es un receptor acoplado a proteinas G y es miembro de la familia de receptores de grelina la cual incluye receptores de neurotensina, motilina, neuromedina asi como el receptor GPR39 (GPR, por sus siglas en ingles G proteincoupled receptor 39).
Funciones de la obestatina y grelina en el organismo Aparato/sistema Funciones Obestatina Receptor GPR39 Aparato Hambre [flecha inferior]- gastrointestinal Motilidad intestinal [flecha inferior]- Vaciado gastrico [flecha inferior]- Peso corporal [flecha inferior]- Polipeptido pancreatico [flecha inferior] Secrecion de insulina [flecha superior] [flecha inferior]- Secrecion acida del - ???
Omeros Corporation (Nasdaq:OMER), a clinical-stage biopharmaceutical company, said on Tuesday that it has identified compounds that interact selectively with each of four additional orphan G protein-coupled receptors (GPCRs), namely GPR15, GPR39, GPR78 and GPR161.
Obestatin was suggested to bind to an orphan G-protein coupled receptor (GPCR), named GPR39 (Pan et al., 2006; Chanoine et al., 2006).
The proposed receptor GPR39 of obestatin had been documented to be down regulated in T2DM associated with obesity5.
Later on, it was found that obestatin binds to the G-protein coupled receptor 39 (GPR39) in these areas of the gut.
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