GPR32

GPR32

A gene on chromosome 14q12 that encodes an orphan G protein-coupled receptor that might be a chemoattractant receptor.
References in periodicals archive ?
It has also been shown that RvD1 could accelerate the airway mucous metaplasia in the resolution of established allergic airway responses.[63] Recently, two GPCRs of RvD1 have been identified and validated using a GPCR/arrestin-coupled system, namely, Orphan GPR32 and ALX.[59] Extracellular signals interact with GPCRs to activate adenylate cyclase/guanylyl cyclase and stimulate formation of the second messenger cyclic adenosine monophosphate/cyclic guanosine monophosphate (cAMP/cGMP), which activates protein kinase A/protein kinase C.
In addition, research has shown, for the first time, that human platelets express the SPM receptors G-protein-coupled receptor 32 (GPR32) and ALX, and maresin 1 regulates platelet hemostatic function by enhancing platelet aggregation and spreading, while suppressing the release of proinflammatory and prothrombotic mediators, indicating maresin 1 could be a novel class of antiplatelet agents that play an important role in the resolution of inflammation in cardiovascular diseases [40].
RvD1 exerts its biological functions through interaction with G-protein-coupled receptor 32 (GPR32) or lipoxin A4 receptor/formyl peptide receptor 2 (ALX/FPR2).
Individual S23 showed evidence of deletion of all of KLK3, along with a long region upstream of KLK3 that included KLK15, KLK1, ACPT (acid phosphatase, testicular), and GPR32 (G protein-coupled receptor 32).
So far, two receptors of RvD1 have been identified: ALX and GPR32. ALX could also be the receptor of lipoxins, while GPR32 being an orphan.