GPR17

GPR17

A gene on chromosome 2q21 that encodes a dual-specificity G protein-coupled receptor for uracil nucleotides, which may mediate brain damage by nucleotides and CysLTs following ischaemia.
References in periodicals archive ?
Abbracchio, "CNS remyelination as a novel reparative approach to neurodegenerative diseases: the roles of purinergic signaling and the P2Y-like receptor GPR17," Neuropharmacology, vol.
Los autores de dicho trabajo intervinieron la proteina G acoplada al receptor 17 (GPR17), una proteina con funciones propuestas en la neuroinflamacion post-isquemica.
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair.
GPR17 and GPR99, recently identified, may also be additional receptors for LTD4/LTC4 [11] and LTE4, respectively [12]; moreover, LTE4 has been reported to upregulate COX-2 through the PPAR[gamma] receptor in mast cells [13], as well as to bind the P2Y12 receptors [14].
Aforementioned, the CysLTs exert their effects by binding to G-protein-coupled receptors [CysLT.sub.1]R and [CysLT.sub.2]R and novels GPR99 [12] and GPR17 [11].
Gelosa et al., "The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair," PLoS ONE, vol.
Ben et al., "Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17," Purinergic Signalling, vol.
That gene is Gpr17 (for G-protein coupled receptor 17), which produces a cell-surface receptor called Gpr17.
To confirm that the receptor is involved in appetite control, the researchers injected a Gpr17 activator into normal mice, and their appetite increased.
Previous research by both labs identified "GPR17," a molecule that prevents immature myelin-making cells called oligodendrocyte precursor cells (OPCs) from maturing.
Indeed, these receptors are phylogenetically related to purinergic P2Y class of GPCRs [4] and evidence reported in the literature suggests the existence of additional receptors responding to CysLTs [5], such as GPR17 [6], GPR99 [7], PPARy [8], P2Y6 [9], and P2Y12 [10].
Once released the effect of nucleotides is exerted via the activation of several specific receptors, namely, P2X1-7 and [P2Y.sub.1,2,4,6,11-14], and perhaps also via cysLT1R, cysLT2R, and/or GPR17 [3, 4].