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Abbracchio, "CNS remyelination as a novel reparative approach to neurodegenerative diseases: the roles of purinergic signaling and the P2Y-like receptor GPR17," Neuropharmacology, vol.
Los autores de dicho trabajo intervinieron la proteina G acoplada al receptor 17 (GPR17), una proteina con funciones propuestas en la neuroinflamacion post-isquemica.
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair.
GPR17 and GPR99, recently identified, may also be additional receptors for LTD4/LTC4  and LTE4, respectively ; moreover, LTE4 has been reported to upregulate COX-2 through the PPAR[gamma] receptor in mast cells , as well as to bind the P2Y12 receptors .
Aforementioned, the CysLTs exert their effects by binding to G-protein-coupled receptors [CysLT.sub.1]R and [CysLT.sub.2]R and novels GPR99  and GPR17 .
Gelosa et al., "The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair," PLoS ONE, vol.
Ben et al., "Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17," Purinergic Signalling, vol.
That gene is Gpr17 (for G-protein coupled receptor 17), which produces a cell-surface receptor called Gpr17.
To confirm that the receptor is involved in appetite control, the researchers injected a Gpr17 activator into normal mice, and their appetite increased.
Previous research by both labs identified "GPR17," a molecule that prevents immature myelin-making cells called oligodendrocyte precursor cells (OPCs) from maturing.
Indeed, these receptors are phylogenetically related to purinergic P2Y class of GPCRs  and evidence reported in the literature suggests the existence of additional receptors responding to CysLTs , such as GPR17 , GPR99 , PPARy , P2Y6 , and P2Y12 .
Once released the effect of nucleotides is exerted via the activation of several specific receptors, namely, P2X1-7 and [P2Y.sub.1,2,4,6,11-14], and perhaps also via cysLT1R, cysLT2R, and/or GPR17 [3, 4].
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