HCAR2

(redirected from GPR109A)

HCAR2

A gene on chromosome 12q24.31 that encodes a G protein-coupled receptor. HCAR2 is a high-affinity receptor for nicotinic acid/niacin and for beta-hydroxybutyrate; it increases adiponectin secretion and reduces lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase.

References in periodicals archive ?

Judd, "Niacin stimulates adiponectin secretion through the GPR109A receptor," American Journal of Physiology-Endocrinology and Metabolism, vol.

Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health

Chen et al., "The effect of metformin on the expression of GPR109A, NF-[kappa]B and IL-1[beta] in peripheral blood leukocytes from patients with type 2 diabetes mellitus," Annals of Clinical & Laboratory Science, vol.

Role of Adaptive and Innate Immunity in Type 2 Diabetes Mellitus

Gpr109A (encoded by Niacr1) is a receptor for butyrate and niacin in the colon.

Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes

At millimolar concentrations BHB blocks the [NLRP.sub.3] inflammasome without undergoing oxidation in the tricarboxylic acid cycle, and independently of uncoupling protein-2 ([UCP.sub.2]), sirtuin-2 ([SIRT.sub.2]), G protein-coupled receptor GPR109A, or hydrocaboxylic acid receptor 2 ([HCAR.sub.2]).

El inflamasoma NLRP3: ?Es realmente una opcion terapeutica para la enfermedad renal?

GPR109a, the third receptor found in the colon epithelium and immune cells, is butyrate-specific and closely associated with the anti-inflammatory effect [41].

Desired Turbulence? Gut-Lung Axis, Immunity, and Lung Cancer

Vieira et al., "Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome," Nature Communications, vol.

Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn's Disease via Modulation of the Gut Microbiota

G-protein- coupled receptor 109 A (GPR109A) was identified as receptors for niacin (Wise et al., 2003).

Dietary niacin supplementation suppressed hepatic lipid accumulation in rabbits

At least three GPCRs have been identified that bind to short chain fatty acids (SCFAs) produced by gut bacteria: GPR41, GPR43, and GPR109A. GPR41 (i.e., FFAR3) and GPR43 (i.e., FFAR2) are both highly expressed on immune cells such as polymorphonuclear cells and macrophages [ 22].

The central role of the gut microbiota in chronic inflammatory diseases

Niacin specifically activates the high affinity G-protein coupled receptors, GPR109a and b, which then leads to release of a variety of prostaglandins that results in the flush response.

Niacin is the safest and most effective way to control cholesterol (but you'd never know it from the media)

The GPR109A receptor is activated by butyrate, a metabolite produced by fiber-eating bacteria in the colon.

How roughage keeps colon cancer at bay

LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B)," Pharmacological Reviews, vol.

Potential Synergies of [beta]-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health

A loss of visfatin in mice adipose tissue impaired adipose tissue functions such as inflammation, severe insulin resistance via the synthesis of nicotinamide that is one of the oldest drugs known for its antilipolytic effects [172], mediated by its interaction with GPR109A, a receptor on the adipocyte plasma membrane [173].

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases