PIGC

(redirected from GPI2)

PIGC

A gene on chromosome 1q23-q25 that encodes a protein belonging to a multimeric complex involved in glycolipid and glycosylphosphatidylinositol-anchor biosynthesis.
References in periodicals archive ?
The Orlean group isolated mutant yeast clones defective in GPI-AP biosynthesis and identified the GPI2 gene involved in the first step.
(1995) Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol: cloning of the GPI2 gene.
(1996) PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. Biochem.
propose that Gpi2 and Gpi19 subunits of the GPI-GnT complex regulate ergosterol synthesis and RAS signaling, which explains the influence of GPI synthesis in the dimorphic switch [139].
Latek et al., "Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol: cloning of the GPI2 gene," Journal of Biological Chemistry, vol.