PIGA

(redirected from GPI anchor biosynthesis)

PIGA

A gene on chromosome Xp22.1 that encodes a transmembrane protein required for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in GPI-anchor biosynthesis.

Molecular pathology
Defects in PIGA cause multiple congenital anomalies-hypotonia-seizures syndrome type 2 and paroxysmal nocturnal haemoglobinuria.
References in periodicals archive ?
The results showed that the TCA cycle, ubiquinone and other terpenoid quinone biosyntheses, N-glycan biosynthesis, other glycan degradation, glycosaminoglycan degradation, GPI anchor biosynthesis, and glycosphingolipid biosynthesis-ganglioseries are the most significant metabolic pathways correlated with CAD genes.
PIGA is involved in the first step of GPI anchor biosynthesis [70].
Lindquist, "Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity," ACS Chemical Biology, vol.